Wednesday, May 20, 2009


ACTN3 is a gene that is beneficial for endurance athletes but is it good for height growth?

α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.

This study found ACTN3 to be associated with reduced bone mass.   ACTN3-KO mice resulted in a non-statistically significant increase in Sox9.  I emailed to find out.

"no evidence for an association between R577X and height, weight, BMI, or WHR in either males or females" was found in the study ACTN3 Genotype, Athletic Status, and Life Course Physical Capability: Meta-Analysis of the Published Literature and Findings from Nine Studies.  Looking directly at the data in the supplement data, the height variation was minor between the various gene expression variations.

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