Thursday, May 2, 2013

Grow taller with Collagen Hydrolysates

Collagen Hydrolysates are available for sale:
Alfa Vitamins Collegen Hydrolysate Nutrition Supplement, 120 Count

This makes it a very promising supplement but the cost of the dosage ratios recommended would be insane but could be up to 25% additional height.  There are 120 pills for $10.  A 50lb kid would take 25 a day to meet the dosage requirements.  So that would be about $2.50 a day.  Which I guess is not that bad.

Porcine Skin Gelatin Hydrolysate Promotes Longitudinal Bone Growth in Adolescent Rats.

"Collagen hydrolysates (CHs) are mixtures of peptides obtained by partial hydrolysis of gelatin that are receiving scientific attention as potential oral supplements for the restoration of osteoarticular tissues. The aim of this study was to evaluate the effectiveness of CHs for promoting longitudinal bone growth in growing rats. An in vitro study was carried out in osteoblast-like MG63 cells and the most effective CH on bone formation was selected among 36 various CHs. An in vivo study confirmed the functional effects of a selected CH with molecular weight of <3 kDa on longitudinal bone growth. CHs dose-dependently promoted the longitudinal bone growth and height of the growth plate in adolescent male rats, whereas gelatin failed to affect longitudinal bone growth. Insulin-like growth factor-1 and bone morphogenetic protein-2 in the CH treated group were highly expressed in the growth plate."

"Collagen is the major constituent of the connective tissues in vertebrates, comprising 30% of total body protein. The denatured form of collagen is referred to as gelatin and is commonly used in foods, pharmaceuticals, cosmetics, and others. To increase the solubility of gelatin, partially hydrolyzed gelatin products have been prepared and are referred to as collagen hydrolysates (CHs)."

3-Week old male Sprague-Dawley rats were used.

"Longitudinal bone growth in normal adolescent male rats was 404.0±11.6 μm/day, and administration of 50 and 250 mg/kg gelatin failed to promote the longitudinal bone growth. However, treatment with 250 mg/kg of CH significantly increased the longitudinal bone growth exhibiting 468.4±27.4 μm/day."<-The dosage for the alfa vitamins collagen above is 1000mg.  So maybe a human should actually take a larger dosage.  250mg/kg is actually pretty insane dosage in terms of cost but growth was over 25% more. That's 550mg/lb.  So a 200lbs individual would have to take 100 pills a day.  50mg/kg still increased height just not statistically significantly.

Here's the growth plate under Collagen Hydrolysate(growth plate height was increased by 11%).
http://online.liebertpub.com/na101/home/literatum/publisher/mal/journals/content/jmf/0/jmf.ahead-of-print/jmf.2012.2461/20130430/images/large/figure3.jpeg
"CHs with molecular weights <3000 Da that is able to increase IGF-1 and BMP-2 protein expression in growth plate, and consequently promote longitudinal bone growth in growing rats."<-the molecular weight of the supplement above is not listed.  Looking it up Collagen Hydrolysate has an average molecular weight of 2000-5000 Da so it's possible that the molecular weight here is over the threshold but humans may be able to tolerate the higher moleculate rate than rats.

Food consumption doesn't seem to be measured but gelatin could serve as sort of a control to that.

24 comments:

  1. Hey Tyler, by itself, would this method be effective in increasing the height of post-pubescent males, or would it need to be implemented in conjunction with an LSJL program? Also, do you think this supplement could be used to treat osteoarthritis or overuse injuries?

    P.S. Thanks for posting these studies; they keep me hopeful.

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  2. i cant understand how you might get 25% extra height.

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  3. Tyler, so if I'm 180lbs and I am still growing then will taking one hundred of these hydrolysate pills a day over the course of say three months increase my height by inches?
    Please respond, im considering buying a hundred of these bottles.

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  4. This comment has been removed by the author.

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    1. I'm honestly not sure. This isn't the kind of supplement that can hurt you. It's just the monetary cost. And I'm not quite sure how the dosages apply to humans.

      Apparently you can overdose on Vitamin C(the supplement I mentioned contains Vitamin C). So you should spread out the tablets.

      From what I read on collagen hydrolysate there is little to no worry about overdose.

      I don't quite understand how the supplement would make you taller either but the results are promising if you have growth plates.

      Results were gotten with lower dosages per bodyweight.

      Possibilities of damage are minimal as long as you spread tablets throughout day. Always check for additional ingredients.

      It's just the monetary cost for a promising study although a very primitive one.

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    2. What can you do to produce chondrocytes like tapping or any supplements?

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  5. People stop believing in this crap! Next time the manlet admin will post a study proving that frequent watering leads plants to grow and it will say water now available for sale.

    This is ridiculous.

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    Replies
    1. What other solutions do you have then

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  6. I still have my doubts if this would work.

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  7. i think it probably does work but its the amount of time it takes and i think their should be more into making it more practical than other thing cause it is after all the main point of this website

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  8. Tyler, Alkaline phosphatase is good or bad for open growth plate ??

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  9. Tyler do you think taking Ecdysterone will be beneficial for lsjl.

    Please give opinion.

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  10. look this tyler.. is about mgp – matrix gla protein (produced by vitamin k2)
    and is the major inhibitor of human body tissue calcification

    and seems to have much influence on chondrocytes:

    http://jcb.rupress.org/content/154/3/659.full

    bonus: Increases Testosterone:

    http://www.ergo-log.com/vitk2testosterone.html

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    1. ''Our results suggest that this increase in MGP expression in association with apoptosis is more than a bystander effect and that MGP is able to stimulate apoptotic pathways either directly or in combination with other factors.'' - from your link about mgp

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  11. Tyler have you been in touch with st.it lately
    Comment back please

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    Replies
    1. I have not heard been in touch with st.it unfortunately.

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  12. omg u r all dumb

    thats an affiliate link of amazon. hes ripping u off

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    1. All the links on the site are amazon affiliate links. I'd rather make a teeny bit of money trying to help people grow taller than by something else.

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    2. Tyler what do you think is best for lsjl cnidium, horny goat weed or Maca. would appreciate it if you could answer for once

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  13. people save your money for a nice car. at least that will get you laid, not some of these shady potentially hazardous pills!

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  14. mechanical loading of cartilage, high-intensity exercise, abnormally large static loading, and a sudden increase in joint loading all lead to OA-like matrix catabolism characterized by decreased collagen networking, proteoglycan loss, and reduced cartilage stiffness . Alterations in joint mechanics that are caused by injury to cartilage or surrounding structures (such as the shock-absorbing meniscus in the knee) would presumably also lead to this type of cartilage catabolism. This would be due to both the production of cytokines as well as the abnormal mechanical loading of the joint caused by tissues damaged by injury . Specifically, cytokines such as IL-1 and TNF-α are inducers of cartilage matrix degradation due to their ability to induce the expression of genes encoding matrix catabolizing proteins such as MMPs and aggrecanases (93, 94). In fact, both IL-1 and TNF-α induce PGE2 production and NO metabolism, which both act as strong catabolic signals in cartilage by promoting chondrocyte injury and enhancing chondrocyte apoptotic potential

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    1. Wow this scares me do you think lsjl can cause OA

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  15. i dont know if you've already heard this but Tenascin and lead induces chondrogenesis.

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  16. Tyler I think you did the math wrong if it's 250 mg per Kg then a 200lbs individual (90,7 kg) would need 22,6 grams of the supplement. That's nearly 23 pills, not 100.

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