Tuesday, October 4, 2011

Height with P70S6K?

LSJL causes a fold change in P70S6K(positive or negative is unclear).  A fold change is predicted but no fold change is shown in the data.

Roles of Ets-1 and p70S6 kinase in chondrogenic and gliogenic specification of mouse mesencephalic neural crest cells.

"Fibroblast growth factors (FGFs) have been shown to promote the chondrogenic and gliogenic specification of mouse mesencephalic neural crest cells through Notch signaling. In the present study, we analyzed FGF signaling pathways in chondrogenic and gliogenic specification. The promotion of chondrogenesis by FGF-2 was significantly suppressed by U0126, an inhibitor of the extracellular signal-regulated protein kinase (Erk) pathway, and by Erk-1 siRNA. Chondrogenesis was also prevented by the dominant negative Ets-1 expression vector[CITED2 downregulates Ets-1 levels; high loading levels do not increased CITED2 levels only moderate loading levels therefore loading has to be high enough not to induce CITED2]. The expression of p70S6 kinase (p70S6k) is activated by both the Erk and Akt pathways."

Maybe if the LSJL loading had been higher more Ets-1 would be produced and more chondrogenesis would be observed.

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