Monday, July 30, 2012

New Growth Spurt by inhibiting DHEA?

DHEA suppresses longitudinal bone growth by acting directly at growth plate through estrogen receptors.

"Dehydroepiandrosterone (DHEA) is produced by the adrenal cortex and is the most abundant steroid in humans. Although in some physiological and pathological conditions the increased secretion of DHEA and its sulfated form is associated with accelerated growth rate and skeletal maturation[note increased adult height is not stated]. In our study, DHEA suppressed metatarsal growth, growth plate chondrocyte proliferation, and hypertrophy/differentiation. In addition, DHEA increased the number of apoptotic chondrocytes in the growth plate. In cultured chondrocytes, DHEA reduced chondrocyte proliferation and induced apoptosis. The DHEA-induced inhibition of metatarsal growth and growth plate chondrocyte proliferation and hypertrophy/differentiation was nullified by culturing metatarsals with DHEA in the presence of ICI 182,780, an inhibitor of estrogen receptor, but not in the presence of Casodex, an inhibitor of androgen receptor. Lastly, nuclear factor-κB DNA binding activity was inhibited by the addition of DHEA in the medium of cultured chondrocyte. Our findings indicate that DHEA suppressed bone growth by acting directly at growth plate through estrogen receptor. Such growth inhibition is mediated by decreased chondrocyte proliferation and hypertrophy/differentiation and by increased chondrocyte apoptosis."

So reducing DHEA to a certain point likely increases growth.  Although likely some levels of DHEA are needed.

"The secretion of DHEA and DHEA-S by the adrenals increases during the adrenarche in children at the age of 6–8 yr, and elevated values of circulating DHEA-S and DHEA are maintained throughout adult life, providing high levels of substrates for conversion into potent androgens and estrogens in peripheral tissues "

"The addition of letrozole did not change the inhibition of DHEA on longitudinal bone growth, indicating that such suppression induced by DHEA was not through its conversion to estrogen but through itself"

Orteronel (TAK-700) according to Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys., suppresses DHEA but it suppresses testosterone and estrogen as well.

According to Correlation of circulating dehydroepiandrosterone with activated protein C generation and carotid intima-media thickness in male patients with Type 2 diabetes., DHEA levels are lower in people with diabetes and that DHEA levels are correlated with c-protein inhibitor complex.  So inhibiting this complex may be a way to lower DHEA levels.

According to ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men., ACE inhibitor's may be an effective way to lower DHEA.  Unfortunately, ACE inhibitors like perendopril are only available by prescription.

Cheese which contains Lactobacillus helveticus may inhibit ACE and thus reduce DHEA.  American Swiss cheese usually contains this probiotic.  Fermented milk may have lactic acid bacteria that also reduce ACE.  So another possibility for how the dutch diet increases height.

7 comments:

  1. HELLO SIR,
    IM NEARLY 5 INCH TALL. ILL BE A SENIOR AT HIGH SCHOOL NEXT YEAR.
    IS THERE ANY PLACE WHERE YOUR BEST METHODS ARE BEING CARRIED ON PATIENTS ?

    ReplyDelete
  2. are you willing to link and work with me and my height increase blog? I think we could be a good team.

    www.naturalheightgrowth.com

    I started it just 10 days ago and have been looking at everything under the sun

    ReplyDelete
    Replies
    1. You are a very good writer. I'll provide you with a link if you mention Yokota's Joint Loading Modality or Robert Ballock's Growth Plate Regeneration research. I'll definitely be following the blog and am interested in collaborations.

      Delete
    2. appreciate the link. i am more interested in ideas, methods, and techniques. most stuff i have found are worthless since this specific niche is filled with so many scams. are you just using a pubmed account to do your research?

      i want to figure something great out within 5-10 years and leave this as a legacy to human kind. i have had a sister, 2 ex-gfs, 2 female cousins, and 3 male friends who have all searched for some solution at some point.

      thanks for the ideas because i'll look into both and the osteon thing you wanted. it will take me maybe 2 weeks before the reviews are done. i have at least 15 posts more to get through. I talked with that other guy and can show you what his ideas are but you have kind of covered them in your blog

      Delete
  3. what do you think about

    Hormones as epigenetic signals in developmental programming
    abigail L. Fowden1 and
    Alison J. Forhead1

    ReplyDelete
  4. @ FLUIDGUIDE .....GREAT JOB MAN...
    keep it up guys......
    its not far that we get our goal even with low budget and all circumstances....
    hats off....:)

    ReplyDelete
  5. does this site get alerts on new comments posted in older blog entries? i posted my ideas in:

    "Grow taller by eating deer antlers?"

    ReplyDelete