Tuesday, August 7, 2012

Tall with Pomegranate or just Puerarin?

Pomegranate is available for sale: Source Naturals Pomegranate Extract 500mg, 240 Tablets

Effects of pomegranate extracts on cartilage, bone and mesenchymal cells of mouse fetuses.

"Pomegranate is a rich source of polyphenols, which are believed to be responsible for the oestrogenic activities of extracts of this fruit in mice. One of these potential activities is the prevention of bone loss. The objectives of the present study were to determine the effects of pomegranate extract on chondrogenesis and osteogenesis in mouse embryos in vivo and limb bud cultures in vitro. A total of fifty pregnant Balb/c mice were given vehicle, pomegranate juice extract (PJE), pomegranate husk extract (PHE) or a mixture of husk and juice extract (PME). Their embryos were stained with alizarin red S and alcian blue, and the length of the femur, tibia and their ossification zones were measured on day 19 of gestation. Bone Ca content in pregnant mice was also measured. Mice treated with PJE showed an increase in bone Ca content. Dietary supplementation with all extracts significantly increased embryo femur length{growth rate though or permanent length} and osteogenesis index. Mesenchymal cells from fetal limb buds were cultured and exposed to 10, 100, 1000 and 10 000 μg/ml of PJE, PHE or PME. The number of viable cells was greater in cultures exposed to the extracts than in control cultures. The number of cartilage nodules and their diameters were greater in extract-treated cell cultures, a finding which reflected increased cell proliferation and differentiation rates."

Pomegranate juice extract increased femur length by about 10%.

Interestingly Pomegranate reduced crown-rump length and body weight.

"Feeding with PJE increased bone Ca content in pregnant mice. "

"pomegranate seed oil contains punicic acid, ellagic acid, steroidal oestrogen, oestrone and non-steroidal phyto-oestrogens including comesten, coumoestrol, and isoflavones, genistein and daidzein"<-since it has so many ingredients some can be height decreasing, neutral, or height increasing.  Genistein jumps out immediately as potentially height decreasing.

"the ossified zones of the limb bones were longer in extract-treated fetuses compared with the controls."

Despite advertisements that POM Wonderful is 50% as effective as Viagra, Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells., states that pomegranate juice reduces cGMP levels meaning that it is not an NO/CNP pathway stimulant like Viagra.

Growth Inhibitory, Antiandrogenic, and Pro-apoptotic Effects of Punicic Acid in LNCaP Human Prostate Cancer Cells., states that Punicic acid may have growth inhibitory effects.

IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid., states that ellagic acid may be associated with IGF-II down regulation.

It's likely that daidzen is the only height increasing compound of pomegranate but it does show that daidzen can overcome potentially height decreasing ingredients for net height gain.

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