Thursday, October 11, 2012

Increase longitudinal bone growth with Colostrum?

Colostrum contains lactoferrin. Symbiotics Colostrum Plus, 240 Capsules is one source of colostrum.  Colostrum may help increase height during development by increasing IGF-1, HGH, and TGF-Beta1 levels.  Eating casein with colostrum may help increase the bio availability of those proteins.  Colostrum may need to be cycled based on lack of benefits on serum levels past 14 days but mice showed no decrease in efficiency to colostrum over time.

Bovine colostrum supplementation and exercise performance: potential mechanisms.

"Bovine colostrum (BC) is rich in immune, growth and antimicrobial factors, which promote tissue growth and the development of the digestive tract and immune function in neonatal calves. Although the value of BC to human adults is not well understood, supplementation with BC is becoming increasingly popular in trained athletes to promote exercise performance. The combined presence of insulin-like growth factors (IGF), transforming growth factors, immunoglobulins, cytokines, lactoferrin and lysozyme, in addition to hormones such as growth hormone, gonadotrophin-releasing hormone, luteinizing hormone-releasing hormone and glucocorticoids. A review of studies investigating the influence of BC supplementation on exercise performance suggests that BC supplementation is most effective during periods of high-intensity training and recovery from high-intensity training, possibly as a result of increased plasma IGF-1, improved intramuscular buffering capacity, increases in lean body mass and increases in salivary IgA. The bioavailability of the active constituents in BC [has not been fully] determined."

"In vivo human studies have demonstrated a significant increase in gastrointestinal villus height and depth following epidermal growth factor administration in neonates with congenital microvillus atrophy"<-so maybe egf has an effect on bone too.

"A reduction in gastrointestinal damage following BC administration in rats has been observed following TGF-β administration. When administered alone, TGF-β is susceptible to digestion with fasting gastric juices, but in the presence of casein, enzyme inhibitors and other peptides contained in BC, the breakdown of growth factors can be prevented, maintaining their activity following ingestion."<-So maybe TGF-Beta in colostrum can affect the bones too.

"[In] rats 9% of IGF-1 ingested alone appears in the bloodstream, while 67% of IGF-1 survives digestion when administered with casein."  Colostrum supplementation increased IGF-1 levels by 25% though this may be due to an increase in exogenous production and not due to the exogenous IGF-1 in colostrum.

"BC supplementation in humans has not been associated with increased plasma nutrient concentrations"

"athletes [were supplemented] with 60 g/day of colostrum and collected blood prior to and following 4 weeks of supplementation for the analysis of IGF-1 and associated binding protein, IGF binding protein-3."  No significant increase in IGF-1 was detected other long term 6-8 weeks have reported no elevation in IGF-1 levels.  Maybe colostrum has to be cycled.  Durations of 8-14 days have resulted in positive increases in IGF-1 but not longer periods.

Effect of a Growth Protein-Colostrum Fraction on bone development in juvenile rats.

"A bovine colostrum 1-30 kDa fraction, Growth Protein-Colostrum (GP-C), was administered to juvenile rats as a dietary supplement to determine effects on growth and development. GP-C enhanced the growth and mineralization of the femur as evidenced by increased serum osteocalcin and bone mineral density. Increased levels of serum growth hormone and insulin-like growth factor-1 suggest that the mechanism of enhanced growth is partially controlled by endocrine factors. GP-C was also found to increase osteoblast proliferation in vitro"

Rat femurs from colostrum fed rats were about 5% longer.  The duration of colostrum feeding was 6.2 weeks.  Rats were 3 week old sprague-dawley rats weighing 50g.  The rats that had 5% of their diet as GP-C gained the most length.  GP-C also seemed to delay senescence as growth rate slowed more in control group than GP-C fed groups.  GP-C effectively increased serum GH and IGF-1 levels.  Serum levels were taken at the conclusion so serum levels remained elevated without a negative feedback mechanism.

The production of GP-C was special and you can read about it in the materials section(the study doesn't let you copy and paste).  GP-C is essentially higher quality than normal colostrum.  Casein was supplemented with the GP-C.

Colostrum also contains miRNA.

Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions.

"In total, 102 miRNA were detected in bovine milk by microarray analysis (100 in colostrum and 53 in mature milk; 51 were common to both). Among these miRNA, we selected several immune- and development-related miRNA, including miR-27b, miR-34a, and miR-130a. These miRNA were detected in bovine milk by quantitative PCR, and each of these miRNA was significantly more highly expressed in colostrum than in mature milk. We also confirmed the presence of some mRNA in bovine milk. Nevertheless, synthesized miRNA spiked in the raw milk whey were degraded, and naturally existing miRNA and mRNA in raw milk were resistant to acidic conditions and RNase treatment. The RNA molecules in milk were stable. We also detected miRNA and mRNA in infant formulas purchased from Japanese markets."

Although none of the miR seemed directly related to bone growth.


  1. is this worth checking?:

  2. @ anonymous ...DAMN ITS GOOD IDEA DUDE
    tyler will it work for height increase?
    stem cell differentiation into osteoblasts and chondroblasts????
    what you think of it?

  3. here is the kit:

  4. it is slightly expensive but it is not too out of reach.

    1. Do you know what is the price?
      It would be great if it could contribute to the height increase.
      Thank you!

  5. they have a youtube page

  6. heck, if we could know how to implant our own stem cells that would be great..

  7. wouldnt that synergize very well with the supplements here, and lsjl and the lipus?

  8. Maybe lsjl showing more results with Mesenchymal Stem Cell.