Thursday, November 15, 2012

Confirmation that the LSJL scientists believed it can cause height growth

Here's a grant submitted by Ping Zhang that was proposed to do research on whether LSJL could cause adult height growth!

Load-Driven Bone Lengthening

"The long-term objective of the proposed project is to understand the mechanism of load-driven bone lengthening. Although distraction osteogenesis is effective to treat the patients with limb length discrepancy, this invasive procedure occasionally generates problems such as premature consolidation, delayed union, and infection. In order to investigate a possibility of load-driven non-invasive therapy[like LSJL], we will focus on knee loading a form of joint loading modalities. We address a set of questions:
(1) Does knee loading enhance proliferation of chondrocytes in the growth plate and lengthen the proliferative and hypertrophic zones in the distal femur and the proximal tibia[if knee loading can cause differentiation of stem cells into chondrocytes it can cause new height growth]?
(2) Is the lengthening effect dependent on ages[will it work on adults?]?
(3) Does injection of insulin growth factor-2 (IGF-2) into the growth plate enhance the loading effects?
We hypothesize
 (a) Lateral loads, applied to the knee with appropriate loading conditions, can lengthen both the femur and the tibia through stimulating proliferation of chondrocytes in the growth plate;
(b) Efficacy of load-driven bone lengthening is stronger in the youth than the elderly;
(c) The lengthening effect can be augmented in the elderly by injecting IGF-1 in the growth plate[so LSJL will work even in aged individuals!!!!  However, aged individuals do not have growth plates so maybe he means injecting IGF-1 into the bone marrow?  I will concede that based on some communications with Ping Zhang that he does not have excellent english skills so perhaps he used the wrong terminology].

In order to examine the above hypotheses, three specific aims are proposed using a hindlimb of C57BL/6 mice as a model system.

Evaluation of load-driven bone lengthening under varying mechanical conditions
Comparison of the loading effects among mice with varying ages
Effects of local administration of IGF-2 into the growth plate with and without knee loading.

We will use a custom-made piezoelectric mechanical loader, and conduct bone histomorphometric and gene expression analyses using varying imaging modalities. The proposed study is expected to contribute to developing a non-invasive physical therapy for treatment of patients with limb length discrepancy.

The proposed project will contribute to examining a possibility of non-invasive physical therapy for treatment of patients with limb length discrepancy"

Here's the grant name to track it: Grant 1R03AR055322-01A1.

Here's a link with more info on the project.  It should be noted that a Salubrinal study is included as part of the grant.  So maybe Salubrinal does have an undisclosed effect on lengthening.

Here's Ping Zhang's research information.


  1. well thats good but still doesn't explain the huge discrepancy in real results.

  2. Tyler,
    How come all the experiments of LSJL are still being done on mice? with all the potential of LSJL it puzzles me how nobody did an experiment on humans...

  3. Wow, I can't wait for the study to finish. This along with the CNP regulation from GTF that one of the forum members already started can really revolutionize things.

    For this i'm just worried about 1= applying enough force to the loading part if it does work and 2= getting a hold of IGF1 or IGF 2. I'm gonna be receiving my M.D. and be a paid physician intern afterwards, so this really intrigues me. Getting some IGF ethically will be a problem.

  4. this is great news!

    Tyler if you havent already i want to suggest that you buy a couple of flash drives small thumb drives and back up all your post from this blog and your important text, just in case. protective procaution in case this site go's down or your hard drive gets short circuited.

  5. i am not convinced lateral force would have more effect on bone width thats not to say it wouldn't increase length but there any other type of method that would directly add longitudal stress to bones would compressive force increase length at the site of stress forcing the bone to grow upwards returning with interest

  6. I'm not sure, but I think rodents still have growth plates when they are adult (although they stop growing), so it might work on adult rodents but maybe not in humans.

  7. i know this would intially shorten the bone but would the bone respond to stress and come back longer than before this might explain why stretching exercises are not effective as the bone recontracts very quickly after stretching is there any way possible to stop the bone recontracting after lengthening

  8. Annonymous #1: Real results may not happen not because the method is ineffective but because of likely a) not enough stimulus(more/harder clamping), b) growth is slow, or c) some supplement may be required(IGF-1 is mentioned maybe a TGF-Beta upregulator like Melatonin could help.

    Guy: You can't sacrifice humans to get measurements when you're done with loading.

    Annonymous #2: Supplements than can increase serum levels of IGF-1 could help. Milk is one such supplement for instance.

    Annonymous #4: Lateral force increases hydrostatic pressure which induces chondrocyte differentiation.

    Annonymous #6: Stretching is not effective I think because you are not actually stretching the bone just the ligaments and soft tissue. Bone stretching should be effective just be definition as when you stretch something and it doesn't return to it's normal size it becomes longer. I have done some research on this.

    1. Tyler, with all your knowledge, how much load time would be effective? Is it better to load strong or weak? Is it necessary to charge the three points of each leg: femur, tibia and ankle? As food supplements or what would you recommend? thank you very much

    2. Tyler, what do you think. why new success stories are not coming out?

  9. hard solid sponge types materials will normally retract to there preditermend length instantly after stretching try it out could a gradual manual stretch be the answer 1mm per day would this be permanent

  10. it depends on the solid you are stretching some materials would hold their stretch eg stretch armstrong toy others retract to original size like sponge others like metal would be very hard to stretch i think bone is a similar to a combination of soft metal hard sponge

  11. what i am saying is soft sponge would hold the stretch but hard spongy type bone would retract instantly even the rubber toy armstrong would go back to its original size so where does that leave us with bone and a solution to increase its length permanently

  12. hey what does this mean?

  13. and this if it can be of
    any leads

  14. So do you want us to go through with the plan and build the prototype for the automatic LSJL device I posted on my website at

  15. Why would you claim that LSJL works if if wasn't already confirmed that it could cause growth? Shouldn't we have moved past this point already? We don't need "confirming" because most people here already believe you.

  16. i think the problems are stem cells,

    we have growth factors which can help the hypertrophy part and known ways to induce chondrogenesis.

    but we need a stem cell population.

  17. Tyler do you have any idea when any of these questions will be investigated?