Monday, October 5, 2009

Ligament ossification genes to LSJL

Ossification of the posterior longitudinal ligament related genes identification using microarray gene expression profiling and bioinformatics analysis.

"A total of 1536 DEGs were screened, with 31 down-regulated and 1505 up-regulated genes. Response to wounding function and Toll-like receptor signaling pathway may involve in the development of OPLL. Genes, such as PDGFB, PRDX2 may involve in OPLL through response to wounding function. Toll-like receptor signaling pathway enriched genes such as TLR1, TLR5, and TLR7 may involve in spine cord injury in OPLL. PIK3R1 was the hub gene in the network of DEGs with the highest degree; INSR was one of the most closely related genes of it."

"bone morphogenetic protein 2 (BMP-2) is found to be a predisposing gene of OPLL[ossifical of the posterior longitudinal ligament]"<-BMP4 and ESR2 are also associated with OPLL.  Can the ossification genes related to this be used to form new growth plates?

Detailed comparison to LSJL genes to be done.

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