Saturday, October 10, 2009


Saa3 is upregulated 3.39 fold by LSJL.

Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases.

"The acute-phase reactant rabbit serum amyloid A 3 (SAA3) was identified as the major difference product in Ag-induced arthritis in the rabbit, a model resembling in many aspects the clinical characteristics of rheumatoid arthritis (RA) in humans. In Ag-induced arthritis, up-regulated SAA3 transcription in vivo was detected in cells infiltrating into the inflamed joint, in the area where pannus formation starts and, most notably, also in chondrocytes. The proinflammatory cytokine IL-1beta induced SAA3 transcription in primary rabbit chondrocytes in vitro. Furthermore, rSAA3 protein induced transcription of matrix metalloproteinases in rabbit chondrocytes in vitro. In the human experimental system, IL-1beta induced transcription of acute-phase SAA (A-SSA; encoded by SAA1/SAA2) in primary chondrocytes. Similar to the rabbit system, recombinant human A-SAA protein was able to induce matrix metalloproteinases' transcription in chondrocytes. Further, immunohistochemistry demonstrated that A-SAA was highly expressed in human RA synovium. A new finding of our study is that A-SSA expression was also detected in cartilage in osteoarthritis."

"In rabbit synovial fibroblasts, SAA3 induces collagenase (matrix metalloproteinase (MMP)-1)"<-Saa3 also induces transcription of MMP-13.

"In resting primary chondrocytes, SAA3 expression could not be detected. Upon stimulation with proinflammatory cytokines like IL-1β and TNF-α, SAA3 transcription is induced. In contrast to previous results that reported PMA-inducible SAA3 expression in synovial fibroblasts"

Induction of serum amyloid A inflammatory response genes in irradiated bone marrow cells. states that Saa3 can be induced in marrow stem cells by radiation.

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